DNA is thermodynamically unstable in aqueous solution a. True b. False The acidi
ID: 78238 • Letter: D
Question
DNA is thermodynamically unstable in aqueous solution a. True b. False The acidic pKa around 3 for a nucleic base such as a purine is best assigned to which of the following groups? a. (=NH-)^+ b. (-NH-) c. -OH d. (=N-) d. -NH_2 The form of DNA most commonly found in chromosomes is a. Z-DNA b. Circular DNA c. Linear single-stranded DNA d. Linear double-stranded DNA The genome of bacteria is in almost all cases a. A circular double-stranded DNA b. Linear single-stranded DNA c. Circular single-stranded DNA d. Double-stranded RNA e. None of the above A solution containing 100mM adenosine plus 100mM thymidine mononucleotides would be expected to have the same absorbance value measured at 260nm as a solution containing 1mM poly-dA plus 1mM poly-dT each chain being 100 bp in length. a. True b. False Pyrophosphate may be considered a "leaving group" in the mechanism of DNA synthesis by DNA polymerases. a. True b. False Which of the following sequences of a single stranded oligonucleotide can form a hairpin structure containing at least four Watson-Crick base pairs row? a. AATTGCTTGCAATCC b. TTGCATGCAATTCCG c. ACATCGATATCGAT d. TATACGATAGCG e. None DNA sequencing by the Sanger method relies on the use ofExplanation / Answer
Answer
1. False because DNA is thermodynamically stable in aqueous solution due to its hydrogen bond formation and base stacking ability
2. Option a is the right answer because -NH+= is comparatively more acid in nature so it will loose the proton at pH 3.
3. Option d is the right answer (Linear double-stranded DNA).
4. option a is the right answer because almost all bacterium having double strand circular DNA.
5. False, because a double strand of poly (A) and Poly (T ) will have a lesser absorbance at 260 nm than free adenosine and thymidine nucleotides. In double strand DNA bases are stacked hence have less absorption of UV light.
6. True, two pyrophosphate group is leaves when one nucleotide adds in growing chain.
7. option A is the right answer because it will make hairpin structure by internal complementary sequence.
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