1. DNA unwinding and topology a. What is required for DNA unwinding at the repli
ID: 256754 • Letter: 1
Question
1. DNA unwinding and topology
a. What is required for DNA unwinding at the replication fork?
b. What are DNA topoisomers? How is DNA topology related to the linking number, writhing and twist?
c. Why must the topology be changed during DNA unwinding?
d. What is required to change DNA topology?
e. What are the mechanistic differences between Type I and II topoisomerases? Similarities?
f. What are the consequences of topoisomerase II inhibition at different stages in the catalytic mechanism?
Explanation / Answer
the process of unwinding or separation of the DNA strand at the replication fork to continue the process of replication is called unwinding.. The topology means the structure, shape, linking no what the DNA maintains is that...
(a) DNA helices are the enzyme which is used for the DNA unwinding...!!
(b) they are the enzyme which are used for the unwinding of the two DNA strand.. It open up the DNA and uses it for replication.. When DNA unwind it twist or writh gets changed.. Linking numbers is associated as twist + writh hence linking numbers changes...
(D) DNA cut or unwinding of the strand is required for the topology change..
(e) type1is used for single stranded cut and type 2 is associated with double stranded cut... The similarities is both changes the DNA topology..!!
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.