The restoration of mismatched base pairs (that occur during replication) or dama

Question

The restoration of mismatched base pairs (that occur during replication) or damaged nucleotides (that happen after DNA replication) in a DNA strand, requires at least three enzymes to repair the damaged DNA molecule. Which option below best describes the known sequence of events in this process? DNA repair polymerase I concurrently removes bases in front and polymerizes the correct sequence behind, as it moves along the template DNA molecule. DNA ligase seals nicks in the repaired strand. a) b) DNA damage is recognized, the newly synthesized strand is identified by an existing nick in the backbone, a section of the new strand is removed by nucleases, the newly created gap is filled by DNA polymerase, and the newly synthesized strand is sealed by DNA ligase. c) a nick in the DNA is tagged, DNA repair proteins replace the wrong base with the correct base, and DNA ligase seals the nick. d DNA damage is recognized by repair molecules, the newly synthesized strand is tagged by an existing nick in the backbone, a section of the new strand is removed by an exonuclease, and the gap is repaired by DNA ligase. ved

Explanation / Answer

The correct option is d) DNA damage is recognized by repair molecules, the newly synthesized strand is tagged by an exiting nick in the backbone, a section of the new strand is removed by an exonuclease, and the gap is repaired by DNA ligase.

The DNA damage is recognized by mismatch repair proteins and new strand is identified by an existing nick in the backbone. The section of new strand is removed by the exonucleases and formed gap is filled by DNA polymerases and the strand is sealed by the DNA ligase.

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