Dogs with short legs have a form of achondroplasia A) From the perspective of th

Question

Dogs with short legs have a form of achondroplasia A) From the perspective of the molecular basis..Give one similarity and one difference when comparing this to human achondroplasia. B) Will a kinase inhibitor be an effective drug for both dogs and humans? Explain your reasoning C) What is one criteria for a kinase inhibitor with respect to it being a safer drug? D) Kinase inhibitors are also useful for treating HER2 positive forms of breast cancer. But the tumors can become resistant to these drugs. Explain the molecular basis for this resistance. E) Once a HER2 cancer line becomes resistant, are there other drugs that could be employed that could still be effective? Explain your reasoning.

Explanation / Answer

Achondroplasia is a form of short leged dwarfism also called autosomal dominant disease.It happense due to mutation in fibroblast growth factor receptor protein(FGFR 3gene) resulting in wheat cartilage or no cartilage formation.The hand and leg bone is effected at the most.The disease is transmited from parents and sometime by new mutation in FGFR 3 gene.

Similarity of disease in Dog and Human

.The mutated nucleotide sequences are 94% identical.

Disimilarity

In human ,muation in G nucleotide at 1138 position of DNA sequence cause achondroplasia. The gene responsible for the achondroplasia is FGFR3 gene

In dogs when G nucleotide mutated to A and C cause achondroplasia.The gene responsible for the achondoplasia is FGFR4 gene. FGFR 4 protein is the partner protein of FGFR3.

B)The thynosin kinase inhibitor receptor is used for control the over activity of FGFR3.As it is also used in cancer therapy ,oncogenic kinase which stimulate mutated FGF3 gene in cervical cancer .It trigger the normal bone growth in mouse grown in lab condition.

C)Tyrosine kinase inhibitor blocks the tyrosine kinase pathway in cancer cells which is responsible for mutated protein production.It cause less bamage to normal cells.It target abnormal protein and blocks it s fuction without any side effects.

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