6. You\'re studying the properties of a non-inactivating voltage-gated sodium ch
ID: 188355 • Letter: 6
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6. You're studying the properties of a non-inactivating voltage-gated sodium channel. You express the channel in a neuron, patch clamp one of the neuron and record in cell-attached mode. The equilibrium potential of sodium in youn system is +55 mV. Assuming that you've isolated a single channel, draw the current as a function of time as you apply the following voltages, labeling channel openings and the direction of the current. -80 mV -40 mV +75 mV You increase the concentration of sodium ions outside the neuron, and again step the membrane potential to -40 mV. What happens to the size of the current? Draw and explain whyExplanation / Answer
In plasma memberane sodium channel are memberane protein through which conduction of sodium ion takes place. sodium channel consist of alpha and beta subunits. These are associated with each other. Here alpha subunit form the core and forms the channel that conduct sodium ion in avoltage gated way.
Voltage gated sodium channel mainly consist of three forms i.e, close, open and inactive. In inactivating voltage gated pottasiun channel at the peak of action potential,when memberane potential become sufficient enough due to enterance of enough sodium ion in neuron then sodium channel become inactive by closing itself and when again memberane voltage become low then this inactivated gate reopen called as Deinactivation. These sodium chnnel conduct electrical impulses in muscles heart and neuron.
Now difference in the concentration of ion on opposite side of memberane causes voltage called memberane potential. In general memberane otential ranges from -40mV to -80mV. Now when interior voltage become less negative then it is called depolarization and when interior voltage become more negative then it is called as hyperpolarization. When voltage lie in between -90 to +100mV then sodium ion always pull the memberane potential up
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