6. You are interested in creating drugs that affect nerve-muscle signaling. At f
ID: 198412 • Letter: 6
Question
6. You are interested in creating drugs that affect nerve-muscle signaling. At first, you wish to create an anesthetic that will prevent nerves from signaling to muscles A. (2pts) What is the identity of one protein in the neuromuscular junction that can be targeted with your drug? B. (5pts) How can a drug affect the molecular function of the protein from Part A to lead to loss of nerve-muscle signaling? C. (5pts) After your success, you then wish to create a drug that prolongs muscle contraction. How can a drug affect the molecular function of the protein from Part A to lead to longer nerve- muscle signaling?Explanation / Answer
A chemical synapse is formed between neuron and muscle fibre. At the neuromuscular junction a chemical synapse is transffered between neuron and muscle fibre. Acetylcholine is released by nephron diffused across the synaptic cleft ad binds to their receptor to sarcolemma. Which cause a cascade of event. Many drugs can destroy the above process and the drug include wuth latrotoxin. It result in release of acetylcholine from presynaptic cell and and influx of calcium directly resulting in muscle contraction or paralysis or sometimes even death.
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