6. You are interested in creating drugs that affect nerve-muscle signaling. At f

Question

6. You are interested in creating drugs that affect nerve-muscle signaling. At first, you wish to create an anesthetic that will prevent nerves from signaling to muscles. A. (2pts) What is the identity of one protein in the neuromuscular junction that can be targeted with your drug? B. (5pts) How can a drug affect the molecular function of the protein from Part A to lead to loss of nerve-muscle signaling? C. (5pts) After your success, you then wish to create a drug that prolongs muscle contraction. How can a drug affect the molecular function of the protein from Part A to lead to longer nerve- muscle signaling?

Explanation / Answer

A chemical synapse is generally formed between neurons and muscle fibres. At the neuromuscular junction, a chemical synapse is transferred between neuron and muscle fibre. Acetylcholine released by neuron diffsed across the synaptic cleft binds to their receptors on sarcolemma which causes a cascade of event. Many dugs can distroy the above process and the drug includes with the latrotoxin. It result in release of acetylcholine from the presynaptic cell and influx the calcium ion directly result in muscle contraction and paralysis or sometimes even death.

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