6. You are interested in creating drugs that affect nerve-muscle signaling. At f
ID: 198336 • Letter: 6
Question
6. You are interested in creating drugs that affect nerve-muscle signaling. At first, you wish to create an anesthetic that will prevent nerves from signaling to muscles. A. (2pts) What is the identity of one protein in the neuromuscular junction that can be targeted with your drug? 8. (Spts) How can dg affect the molecular function of the protein from Part A to lead to loss of nerve-muscle signaling? C. (5pts) After your success, you then wish to create a drug that prolongs muscle contraction. How can a drug affect the molecular function of the protein from Part A to lead to longer nerve muscle signaling?Explanation / Answer
A chemical synapse is genetally formed between neuron and muscle fibre. At tge neuromuscular junction, a chemical synapse is generally formed between neuron and muscle fibre. The acetlcholine ia relesed from neuro and diffused across the synaptic cleft and binds to their receptors on sarcolemma. Which causes a cascad of event. Many drugs can destoy the above process and the drug include with latrotoxin. It result in relese of acetylcholine from presynaptic cell and influx of calcium ion directly which result in muacle contraction and paralysis and sometime even death.
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