6. You are interested in creating drugs that affect nerve-muscle create an anest
ID: 199010 • Letter: 6
Question
6. You are interested in creating drugs that affect nerve-muscle create an anesthetic that vwill prexvent nerves from signaling to muscles. signaling. At first, you wish to (2pts) What is the identity of one protein in the neuromuscular junction that can be targeted with your drug? 8. (5pts) How can a drug affect the molecular function of the protein from Part A to lead to loss of nerve-muscle signaling? C. (5pts) After your success, you then wish to create a drug that prolongs muscle contraction. How can a drug affect the molecular function of the protein from Part A to lead to longer nerve- muscle signaling?Explanation / Answer
The protein to is a postsynaptic receptor also called nicotinic acetylcholine receptor that the drug will go bind for stopping signal transmission .
Usually what happens is that the ions channels open to open to let sodium ions flow across membrane in the muscle cells and generated an action potential and travel to myofibril and cause muscle to contract but binding of this drug to the receptor will seize the sodium ions to be released for generation of membrane potential
For prolong muscle contraction the receptor that binds to acetylcholine is constantly activated this can be achieved by triggering the receptor via drug that binds to the receptor at all time so that even when acetylcholine is not being synthesised by the cell these receptor are always active to prolong muscle contraction.
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