write about 5 different ways nanoparticles could be used to diagnose or treat di
ID: 53570 • Letter: W
Question
write about 5 different ways nanoparticles could be used to diagnose or treat diabetes type 1. For each case, think about… What do you want your nanoparticles to accomplish? What types of biological barriers do you need to overcome? What materials would you use and why? What sorts of physical characteristics are important to consider when designing nanoparticles for your disease application? Do you need to release a drug, and if so, should the drug be released slowly or quickly? What patients would benefit from this treatment? If these nanoparticles only treat a sub-set of patients, how could you change your design to reach more patients?
Explanation / Answer
Nanoparticle use in type 1 diabetes.
Nanoparticles developed as imaging contrast agents helps in early diagnosis of diabetes.
Glucose nanosensors incorporated in implantable devices helps to track real time tracking of blood glucose levels.
Glucose responsive nanoparticles provide insulin based on physiological needs.
Nanoparticles are also used to deliver insulin using non invasive approach.
Biological barriers to overcome - The biological barriers such as blood brain barrier, skin, nasal cavity, mucosa and intestine should be considered.
Materials for nanoparticles - Peptides, lipids, synthetic polymers, inorganic metal ions etc can be used. But they should not be toxic for the normal cell and should be inert in the physiological condition.
Physical properties - Physical properties such as size and temperature stability is more important with respect to nanoparticles.
Drug to be released - The drug in this case is insulin. It has to be delivered upon insulin need in the body neither quickly nor slowly.
Patients to benefit from treatment - It can help to treat patients with type 1 diabetes. Non insulin dependent diabetes should also be taken into consideration.
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