Several human genetic diseases, such as phenylketonurea (PKU), Tay-Sachs, sickle

Question

Several human genetic diseases, such as phenylketonurea (PKU), Tay-Sachs, sickle-cell anemia, and muscular dystrophy, are caused by deleterious recessive alleles. Affected individuals who inherit 2 of the recessive alleles have a decreased life expectancy and are less likely to reproduce than those that are heterozygous or homozygous for the dominant normal allele. Describe the effect natural selection will have on the frequency of the alleles for such genetic disorders if the original frequency of the recessive 1%. Will the frequency of the recessive allele (1) increase, (2) decrease, or (3) stay the same? Explain your allele is answer. Think about a large population over 25 to 50 generations.

Explanation / Answer

Ans: We can'nt say, as the population increases there is a chance of increase the frequency of alleles change.If the population is less there is a chance of decrease or stable in frequency of alleles change and also it is likely that it will have reduced genetic diversity.

Genetic Drift is the change in allele frequency due to change and may include the loss of alleles from the gene pool.when populations are large, mating is random and environmental is stable,the frequency of alleles tends to remain stable from generation to generation.this as nothing to do with natural selection.However, when populations become small, the allele frequencies can increase, decrease or even be completely loss by change alone.

Migration ia the movement of one population to another.EMMigration and MMigration are the two processes allow for GENE flow between populations.If population are large, migration will have less or no effect on allele frequency.If populations are small, migration may have a big impact on allele frquency.

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