BIOL3300K Applications in Virology Scenario Reading: Antiviral medications are a
ID: 214427 • Letter: B
Question
BIOL3300K Applications in Virology Scenario Reading: Antiviral medications are a subgroup of antimicrobial drugs which specifically act to: 1) prevent of a virus to its target host cell, 2) prevent penetration of a virus into the target host cell, 3) prevent genome replication of the virus once it is inside the host cell, 4) prevent integration of attachment viral DNA into the s genome, 5) prevent the nascent viral proteins from being processed into functional protelns, 6) prevent the release of mature viruses from the infected host cel Depending on the actual virus, some of these drugs completely preventing infection, some halt the progress of the viral infection, and some will have no effect whatsoever. Consider the mechanism of action of each drug (or antibody) and how it may affect (or not affect) both HIV and influenza viruses. For simplicity's sake, use the following as the general stages in viral infection/replication cycles: attachment, penetration/uncoating, synthesis of the genome, synthesis of viral proteins, assembly of new vi and release of mature virions. The following drugs will be evaluated as potential antiviral drugs for treatments of various viral diseases: o Fuzeon: binds specifically to gp41. o Isentriss: interferes with viral DNA insertion into host DNA o Permavir: blocks action of neuramidinase o Prezista: inhibits HIv-1 protease o Selzentry: binds to CCR5 receptors on host cells o Retrovir: also known as AZT, analog to thymidine o Intelence: binds to reverse transcriptase o Rebetol: also known as Ribovir, guanosine is an analog for guanine o Pirodavir: binds preferentially to capsid proteins found in picornaviruses Discussion Questions: 1. Predict which STEPISTEPS of viral replication which each drug will MOST LIKELY interfere with for each drug. 2. Predict whether each drug MAY BE an effective treatment for the following viral infections: a) HIV, b) Influenza, c) Feline Immunodeficiency Virus (FIV), d) Human Respiratory Syncytial Virus (RSV) and e) poliovirus. Provide a brief explanation supporting your decision.Explanation / Answer
1. Fuzeon interfere with the gd41 surface receptors of HIV during attachment to the host cell or can inhibit the synthesis pf viral protiens like gd41. Isentriss interfere with the isertion of viral DNA which is formed from viral RNA by the enzyme reverse transcriptase. After virus replication inoreder to release fro the host cell the virus like influenza produses neuraminidase enzyme this enzyme is inhibited by permavir. During attachment step the virus like HIV recognise the specific receptors for attachment one of the receptors is CCR5 so the drug seizentry is used to treat the virus. During DNA synthesise the drug retrovir also known as AZT interfere with the nucleotide where it acts as analog to the thymidine. Intelence is the drug intefere with virus during for mation of DNA from RNA by reverse tranacriptase. Rebetol which is analog to guanine and can cause mutations during DNA synthesis or formation of genetic material. Pirodavir attach to the receptors of virus during attachment step. During the synthesis of polyprotiens like gag and gag-pol the drug prezista show effective.
2.Fuzeon, insentriss, prezista, intelence , retrovir, rebetol and selzentry are the drugs show effective treatment against HIV. Permavir show effective against influenza. Retrovir show effective treatmeant against feline immunodeficiency virus.Ribavirin for human respiratory syncytial virus.Pirodavirt show effective against polio virus.
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