PLEASE REFER TO DIAGRAM BELOW 1. What chromosomal abnormality/abnormalities do y

Question

PLEASE REFER TO DIAGRAM BELOW

1. What chromosomal abnormality/abnormalities do you observe in this karyotype? (Be as specific as possible in your answer).

2. Which of the following mutagens most likely generated the abnormality seen here? Check all that apply.

a. An error by DNA polymerase during replication

b. An error by RNA polymerase during transcription

c. An error by ribosomes during translation

d. Reactive Oxygen Species

e. UV light exposure

f. X ray exposure

g. Incorporation of a 5-Bromo- Uracil

h. Exposure to Ethidium Bromide

i. Depurination

3. Which of the following repair mechanisms was likely involved in the abnormality(ies) seen in this karyotype? Check all that apply.

a. Proofreading by a polymerase

b. Mismatch repair

c. Base Excision Repair

d. Nucleotide Excision Repair

e. Photolyase

f. Homologous Recombination

g. Non-Homologous End Joining

4. Give 3 ways in which the abnormality(ies) in this karyotype could lead to a phenotype.

QUESTION 3: Below is a human karyotype L2 s3 14 as 16 1s 20 A) What is the sex of this individual? B) Which of the following best describes the chromosomes in the karyotype: 1N, 2N, 4N, 23N, 46N? Explain your choice

Explanation / Answer

1. One of the abnormality is the deletion in the long arm of the chromosome 7.Another abnormality is the deletion in the long arm of chromosome 12.

2. All of these options holds true c,e,and f

3. All of these were most likely repair mechanisms lead to the abnormality a,c,and e

4. Chromosome 7q deletion phenotype exhibit retardation of growth and mental ability and they will have elf like appearance.Chromosome 12q deletion will exhibit with various pheotype ncluding left lip, malformed bones, behavioural abnormalities, etc..

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