Proteins that are targeted to reside near the surface of the plasma membrane on

Question

Proteins that are targeted to reside near the surface of the plasma membrane on the cytosolic side of the membrane can be prenylated (attachment of an isoprene unit) by post-translational modification. Inhibition of what enzyme could have effects on protein targeting? Cox-1/Cox-2 Acetyl-CoA carboxylase Fatty acid synthase HMG-CoA reductase Fatty acyl-CoA synthetase The ____ (1) ___ protein in DNA polymerase III serves the same function as ____ (2) ___ in eukaryotic replicase. (1) single strand binding (SSB): (2) FEN1 (1) DnaB: (2) MCM (1) core polymerase: (2) DNA polymerase alpha (alpha) (1) primase: (2) PCNA (1) beta (beta) clamp: (2) RFC

Explanation / Answer

HMG- CoA reductase.

DnaB and MCM.

for more information refer to the link below-

https://en.wikipedia.org/wiki/Prenylation

https://en.wikipedia.org/wiki/DnaB_helicase

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786579/

http://www.jbc.org/content/279/44/45586.full

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