Protein kinase B has a pleckstrin homology domain and is downstream of insulin r
ID: 841379 • Letter: P
Question
Protein kinase B has a pleckstrin homology domain and is downstream of insulin receptor signaling. All of the following are true with regards to protein kinase B EXCEPT: It is tethered to the cell membrane when bound to phosphatidylinositol trisphosphate
It is activated by phosphoinositide-dependent kinase 1 (PDK1)
It is activated when is is phosphorylated.
It directly interacts with PI3-kinase (phosophatidylinositol 3' kinase)
If a chemical messenger is secreted by a cell and that hormone is sensed (thru receptor ligand interactions) by a neighboring cell and the cell that secreted the hormone, this chemical messenger could be classified as a(n):
Endocrine hormone
Paracrine hormone
Both a paracrine and an autocrine hormone
Both an endocrine hormone and a paracrine hormone
The reaction catalyzed by phospholipase C involves all of the following EXCEPT:
Inositol trisphosphate as a product
Diacylglycerol phosphate as a product
Phosphitidylinositol bisphosphate as a substrate
Diacylglycerol as a product
Which of the following best describes the mechanism of action of cortisol?
It binds a Jak-STAT receptor on the cell membrane
It binds a serine-threonine kinase receptor to elicit a cellular response
It initiates a Map Kinase cascade
It binds an intracellular receptor and functions as a transcription factor
The mitogen activated protein kinase kinase kinase cascade (MAPKKK) is a downstream part of a receptor tyrosine kinase signaling cascade. The step that initiates the MAPKKK involves:
Autophorphorylation of the receptors
Grb binding to the phosphotyrosine in the cytosolic domain of the receptor
The interaction of SOS with Ras-GDP
The binding of Ras-GTP to Raf
Endocrine hormone
Paracrine hormone
Both a paracrine and an autocrine hormone
Both an endocrine hormone and a paracrine hormone
The reaction catalyzed by phospholipase C involves all of the following EXCEPT:
Inositol trisphosphate as a product
Diacylglycerol phosphate as a product
Phosphitidylinositol bisphosphate as a substrate
Diacylglycerol as a product
Which of the following best describes the mechanism of action of cortisol?
It binds a Jak-STAT receptor on the cell membrane
It binds a serine-threonine kinase receptor to elicit a cellular response
It initiates a Map Kinase cascade
It binds an intracellular receptor and functions as a transcription factor
The mitogen activated protein kinase kinase kinase cascade (MAPKKK) is a downstream part of a receptor tyrosine kinase signaling cascade. The step that initiates the MAPKKK involves:
Autophorphorylation of the receptors
Grb binding to the phosphotyrosine in the cytosolic domain of the receptor
The interaction of SOS with Ras-GDP
The binding of Ras-GTP to Raf
Explanation / Answer
Protein kinase B has a pleckstrin homology domain and is downstream of insulin receptor signaling. All of the following are true with regards to protein kinase B EXCEPT: It is tethered to the cell membrane when bound to phosphatidylinositol trisphosphate
It is activated by phosphoinositide-dependent kinase 1 (PDK1)
It is activated when is is phosphorylated.
It directly interacts with PI3-kinase (phosophatidylinositol 3' kinase)
If a chemical messenger is secreted by a cell and that hormone is sensed (thru receptor ligand interactions) by a neighboring cell and the cell that secreted the hormone, this chemical messenger could be classified as a(n):
Endocrine hormone
Paracrine hormone
Both a paracrine and an autocrine hormone
Both an endocrine hormone and a paracrine hormone
The reaction catalyzed by phospholipase C involves all of the following EXCEPT:
Inositol trisphosphate as a product
Diacylglycerol phosphate as a product
Phosphitidylinositol bisphosphate as a substrate
Diacylglycerol as a product
Which of the following best describes the mechanism of action of cortisol?
It binds a Jak-STAT receptor on the cell membrane
It binds a serine-threonine kinase receptor to elicit a cellular response
It initiates a Map Kinase cascade
It binds an intracellular receptor and functions as a transcription factor
The mitogen activated protein kinase kinase kinase cascade (MAPKKK) is a downstream part of a receptor tyrosine kinase signaling cascade. The step that initiates the MAPKKK involves:
Autophorphorylation of the receptors
Grb binding to the phosphotyrosine in the cytosolic domain of the receptor
The interaction of SOS with Ras-GDP
The binding of Ras-GTP to Raf
please check the answer which are bolded are 100% correct answers
Endocrine hormone
Paracrine hormone
Both a paracrine and an autocrine hormone
Both an endocrine hormone and a paracrine hormone
The reaction catalyzed by phospholipase C involves all of the following EXCEPT:
Inositol trisphosphate as a product
Diacylglycerol phosphate as a product
Phosphitidylinositol bisphosphate as a substrate
Diacylglycerol as a product
Which of the following best describes the mechanism of action of cortisol?
It binds a Jak-STAT receptor on the cell membrane
It binds a serine-threonine kinase receptor to elicit a cellular response
It initiates a Map Kinase cascade
It binds an intracellular receptor and functions as a transcription factor
The mitogen activated protein kinase kinase kinase cascade (MAPKKK) is a downstream part of a receptor tyrosine kinase signaling cascade. The step that initiates the MAPKKK involves:
Autophorphorylation of the receptors
Grb binding to the phosphotyrosine in the cytosolic domain of the receptor
The interaction of SOS with Ras-GDP
The binding of Ras-GTP to Raf
please check the answer which are bolded are 100% correct answers
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