Proteins that are targeted to reside near the surface of the plasma membrane on

Question

Proteins that are targeted to reside near the surface of the plasma membrane on the cytosolic side of the membrane can be prenylated (attachment of an isoprene unit) by post-translational modification. Inhibition of what enzyme could have effects on protein targeting? Cox-1/Cox-2 Acetyl-CoA carboxylase Fatty acid synthase HMG-CoA reductase Fatty acyl-CoA synthetase The____ (1)___ protein in DNA polymerase lll serves the same function as___ (2) ____ in eukaryotic replicase. single strand binding (SSB): (2) FEN1 (1) DnaB: (2) MCM (1) core polymerase: (2) DNA polymerase alpha (alpha) (1) primase: (2) PCNA (1) beta (beta) clamp: (2) RFC

Explanation / Answer

Ans. 22: Option 4. HMG CoA reductase

HMG CoA reductase involved in production of isoprenoids. Thus inhibition of this process causes decreases in isoprenoids conc. in cell thus stops the prenylation process.

Ans. 23: Option 5. 1) Beta clamp. 2) RFC

Both these proteins acts like clamp loader during replication while polymerase sliding through the DNA chain.

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