please answer question 2 and 3 please Cell Cycle and Cancer Cancer is often refe
ID: 94445 • Letter: P
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please answer question 2 and 3 please Cell Cycle and Cancer Cancer is often referred to as a disorder of the cell cycle (see p 128 in your book). 1. Briefly describe the cell cycle and explain how it is regulated. 2. How might disruption of the cell cycle lead to cancer? 3. Find and describe the actions of a chemotherapeutic agent that directly targets the cell cycle. Be sure to explain specifically when during the cell cycle it works and what it interferes with. Here is a good resource to get you started in finding a chemotherapeutic agent to discuss: National Cancer Institute. 2012. Types of chemotherapy drugs http: //training.seer.cancer.gov/treatment/chemotherapy/types.htmlExplanation / Answer
1) cell cycle has 2 main phases : interphase and mitosis
interphase is further divided into : G1 (growth 1), S (synthesis), G2(growth 2)
cell prepare for DNA replication during G1, DNA replication occurs during S phase and preparation for mitosis/division occurs during G2
Mitosis has 5 phases : prophase (condensation of DNA begins and nuclear membrane begins to dissappear), metaphase (chromosomes align along the metaphasic plate), anaphase(chromatids are pulled away towards opposite poles), telophase (nuclear membrane begis to reappear and chromosomes unwind) , cytokinesis (cell division).
It is regulated at various check points witht he help of cyclin-CDK (cyclin dependant kinase) complexes.CDK are always present. Levels of cyclins oscillate throughout the cell cycle. when a articular cyclin goes up CDK-yclin complex is formed and CDK is now active to phosphorylate downstream proteins which help the cell to cross the check point and enter the successive phase of the cell cycle.
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