A human \"B\" cell is capable of producing about 15 million IgG proteins by usin

Question

A human "B" cell is capable of producing about 15 million IgG proteins by using: A) Recombination process. B) alternative splicing process. C) changing the composition of transcription factors D) inducing point mutation. E) Inserting transposons. The following phenotypic change of a bacterium is possible by transfer of DNA by "conjugation". A) ability to produce toxin. B) Develop antibiotic resistance. C) Production of virulence factor D) All of the above statements are true. The following features is (are) the requirement(s) for homologous recombination to occur: A) Very similar (homologous) DNA sequences are required. B) The site of exchange can be anywhere in the homologous sequences. C) Nucleotide sequences do not alter at the site of exchange. D) Enzymes are required to cut both strands of the double helix. E) All of the above.

Explanation / Answer

13) Alternative splicing also known as differential splicing is a key component of eukaryotic gene expression. Alternative splicing is defined as a process in which exons or portions of exons or noncoding regions within a pre-mRNA transcript are differentially joined or skipped, resulting in multiple protein isoforms being encoded by a single gene. Humans are able to synthesize many different kinds of proteins with the help of only 20,000 genes with the help of alternate splicing. Therefore, human B cells are able to produce 15 million IgG proteins by using alternate splicing process (option B).

14) Conjugation is the transfer of genetic material from one bacteria to another with the help of sex pili. This transfer of new genetic material confers the ability to produce toxins (C.diptheriae), develop antibiotic resistence (S.aureus,K.pneumoniae) and production of virulence factor (E.coli). Therefore, the correct answer is option (D).

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