A substitution mutation occurs in the GRE (glucocorticoid response element) maki

Question

A substitution mutation occurs in the GRE (glucocorticoid response element) making it unrecognizable to the glucocorticoid receptor.

What impact would this have on the transcription of the gene downstream of this element?

1) transcription unchanged but mutation incorporated into transcript

2) transcription unchanged but translation increased

3) increased translation of downstream gene

4) decreased translation of downstream gene

Please explain! I am having trouble understanding the concept behind this... THanks!

Explanation / Answer

Ans.) “A” Transcription unchanged but mutation incorporated into transcript

(Mutation in glucocorticoid response element making it unrecognizable to the glucocorticoid receptor and eventually halts the cell replication, reproduction which leads to death. In addition, if the mutation takes place in the region where transcriptional machinery binds to the protein, the mutation can have an effect on the binding of the transcription factors because the short nucleotide sequences recognized by the transcription factors will be amended. This substitution mutation could affect the competence of gene transcription, which on the other hand changes the configuration of mRNA and thus, protein levels is also altered in general. Basically, this mutation results in change in short sequence which consequently changes the binding of transcription factor to protein.

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