a 20 years old male found unconscious on a street. he smalledof alcohol. after i

Question

a 20 years old male found unconscious on a street. he smalledof alcohol. after intravenous administration of glucose, thepatient quickly regained consciousness. patient said he had noteaten for 4 days, his main intake is vodka. (his blood thiaminelevel also below normal) blood sample results:                           PATIENT       NORMAL Value glucose(mM)         1.8             4.0-6.0 pyruvate (mM)        0.08           0.04-0.1 lactate(mM)           4.7             0.6-2.0 ehtanol(%)              0.03           0.0 (if higher than 0.08 = intoxicated) Bicarbonate (mM)   21.9            24-28 PH                          7.31           7.35-7.45 Q1 --> what is the main source of the man's blood glucosewhen he found unconscious? Why? Q2 --> ehtanol is metabolized in the liver first toacetaldehyde and then to acetate, with production of NADH at eachstep. explain how the elevated level of NADH that would result isresponsible for his elevated blood lactate level and low bloodglucose. (related questions of Q3-Q4, Q5-Q6 are on the other topicheadline.)   a 20 years old male found unconscious on a street. he smalledof alcohol. after intravenous administration of glucose, thepatient quickly regained consciousness. patient said he had noteaten for 4 days, his main intake is vodka. (his blood thiaminelevel also below normal) blood sample results:                           PATIENT       NORMAL Value glucose(mM)         1.8             4.0-6.0 pyruvate (mM)        0.08           0.04-0.1 lactate(mM)           4.7             0.6-2.0 ehtanol(%)              0.03           0.0 (if higher than 0.08 = intoxicated) Bicarbonate (mM)   21.9            24-28 PH                          7.31           7.35-7.45 Q1 --> what is the main source of the man's blood glucosewhen he found unconscious? Why? Q2 --> ehtanol is metabolized in the liver first toacetaldehyde and then to acetate, with production of NADH at eachstep. explain how the elevated level of NADH that would result isresponsible for his elevated blood lactate level and low bloodglucose. (related questions of Q3-Q4, Q5-Q6 are on the other topicheadline.)  

Explanation / Answer

      Q1)   Fromthe above given data the concentrationm of lactate is more in theunconsicious patient.                Thereforeit is evident that the amin source of man's blood glucose whenunconsicious is lactate.                Bythe process of gluconeogenesis, lactate is converted to glucose andsreves as the source of glucose at the time                ofunconsiciousness.
      Q2)   The NADHthat is produced when Ethanol is converted to acetaldehyde andthen to acetate in liver is used in the                processof anaerobicglycolysis.                Whichmeans that the NADH that is released is used in the conversion ofpyruvate tolactate that isformed during                 glycolysis.                Duringglycolysis, glucose is converted to pyruvate which has a diversefate; that is in the presence of oxygen it is                furtheroxidized through TCA cycle and in the absence of oxygen it isconverted to lactate.                Inthe above condition as NADH is produced by the conversion ofethanol to acetaldehyde and acetate; the                releasedNADH is used toconvert the formed pyruvate to lactate.                Dueto this, the patient has high levels of lactate and low levels ofglucose.

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