The steps of mismatch repair in E. coli replication are given below. Note that i

Question

The steps of mismatch repair in E. coli replication are given below. Note that in this case the mismatch is on the 3' side of the partially methylated DNA sequence. Complete the sentences by moving the correct term to each blank. Not all the terms will be used, and two terms will be used more than once. 3' sequences; for a short time, the new, complementary The template strand is methylated at 5- strand is not. A DNA duplex that has only one methylated strand is forms a complex with MutS at the mismatched base pair. A loop is formed as complex interact, and (bound to the partially methylated sequence) and the -Muts cuts the nonmethylated strand. A(n) mismatch site degrades the nonmethylated DNA strand between the cleavage site and just beyond the DNA fills in the gap. DNA joins the nick. CTAG polymerase III ligase GATC Muts bimethylatedexo ease MutH

Explanation / Answer

The template strand is methylated at 5- GATC -3 sequences; for a short time, the new, complementary strand is not.

A DNA duplex that has only one methylated strand is hemimethylated.

MutL forms a complex with MutS at the mismatched base pair.

A loop is formed as MutH (bound to the partially methylated sequence) and the MutL -MutS complex interact, and MutH cuts the non-methylated strand.

A(n) exonuclease degrades the non-methylated DNA strand between the cleavage site and just beyond the mismatch size.

DNA polymerase III fills in the gap.

DNA ligase joins the nick.

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