1) Dogs with short legs have a form of achondroplasia. A) (2 points) From the pe
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Question
1) Dogs with short legs have a form of achondroplasia. A) (2 points) From the perspective of the molecular basis. Give one similarity and one difference when comparing this to human achondroplasia. B) (2 points) Will a kinase inhibitor be an effective drug for both dogs and humans? Explain your reasoning C) (2 points) What is one criteria for a kinase inhibitor with respect to it being a safer drug? D) (3 points) Kinase inhibitors are also useful for treating HER2 positive forms of breast cancer. But the tumors can become resistant to these drugs. Explain the molecular basis for this resistance E) (3 points) Once a HER2 cancer line becomes resistant, are there other drugs that could be employed that could still be effective? Explain your reasoning.Explanation / Answer
1)FGFR3 fibroblast growth factor receptor 3 is responsible as negative regulator of linear bone elongation for both humans and dogs
In dogs there is variation in FGFR3 exons, promoter region or its molecular structure that is the gene is conserved but in case of humans FGFR3 is having 19 variation s of exons.
2))kinase inhibitor is effective in both dogs and human as it inhibits the function of FGFR3 which is a tyrosine kinase FGFR3 has two parts one extra cellular one intracellular this intracellular part is responsible for recieving and transmitting signals the intracellular part are rich in tyrosinase which are hidden in atp pockets after recieving signal the FGFR3 configuration changes and it acts from this atp pockets but kinase inhibits atp pockets from functioning and FGFR3 action is inhibited.
3)) tyrosinase inhibitor is a safer drug because it can be used in cancer therapy it does not have any cardiotoxic effect
4.))Tumors are resistant to kinasr inhibitor
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