Rate of drug self-administration is: a. a perfectly reliable and accurate measur
ID: 3493243 • Letter: R
Question
Rate of drug self-administration is:
a. a perfectly reliable and accurate measure of a drug’s abuse liability.
b. an imperfect measure of the abuse liability of a drug because the motor effects of some readily abused drugs may interfere with an animal’s ability to produce an operant response.
c. an inaccurate measure of a drug’s abuse liability because all readily abused drugs are highly reinforcing, thereby producing a ceiling effect on operant responding.
d. inversely related to the abuse liability of a drug.
e. tremendously difficult to interpret, as a measure of the abuse liability of a drug, and is therefore rarely assessed in animal research.
Explanation / Answer
Option a
An accurate estimate of the abuse liability of a new drug informs the decisions of the commercial sponsor,governmental agencies, and ultimately,the physicians and patients who might use the drug product.In the process of drug development, a commercial sponsor must make a number of decisions when designing clinical trials, safety and commercial risks,implementing risk mitigation strategies,and designing postmarketing surveillance programs,each of which are affected by the abuse liability of the drug under development.Abuse liability assessment is also important for the physicians who will prescribe and for the patients who will use new therapeutic drugs. Both physicians and patients should be aware of the potential risks and benefits of a therapeutic drug,including its abuse liability. No drug is completely safe and every drug has specific risks associated with its use.
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