1.) People with a genetic condition known as Li-Fraumeni syndrome inherit one mu
ID: 262686 • Letter: 1
Question
1.) People with a genetic condition known as Li-Fraumeni syndrome inherit one mutatedcopy of the TP53 gene. These people have a high risk of developing a number ofdifferent cancers, such as breast cancer, leukemia, bone cancer, adrenocortical tumors,and brain tumors. Explain how mutations in one cancer-related gene can give rise tosuch as diverse range of tumors.
2.) Of the two classes of genes associated with cancer, tumor-suppressor genes and
oncogenes, mutations in which group can be considered gain-of-function mutations? In
which group are the loss-of-function mutations? Explain.
Explanation / Answer
P53 gene is involved in the regulation of transcription and it is a tumor suppressor gene and mutation in both of the copy of tumor suppressor gene leads to loss of function mutation.It leads to development of bone cancer,breast cancer and brain tumor.
2)Gain of function is related to protooncogenes.Protooncogene are the normal gene which due to gain turns into oncogenes which leads to development of cancer.Mutation in one of the copy of Protooncogene leads to gain of function.Loss of function mutation is present in tumor suppressor genes.These genes inhibit the formation of tumor.When there is loss of function mutation in both the copies of gene then it leads to occurrence of tumor or cancer.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.