1.) Localized delivery of a pharmacologic agent to the GI tract is used to disru
ID: 3506641 • Letter: 1
Question
1.) Localized delivery of a pharmacologic agent to the GI tract is used to disrupt the actin cytoskeletal network within the columnar epithelium lining the tract.
a.) What changes in epithelium structure and/or function would you predict to occur, assuming the epithelial cells lack a compensatory mechanism for the disruption?
b.) Briefly explain (1-2 sentences) your answer for a
c). Consider the flow of “information” in a neuron.How is “information” transmitted in the axon?
d.) Identify the 2 types of voltage-gated channels involved in this information transmission and state the contribution of each type of channel.
e.) Where does communication occur between two neurons?
f.) What voltage-gated channel is involved in chemical communication between two neurons and how does it contribute?
Explanation / Answer
a. These drugs cause structural defects in the integrity of the epithelium and cause problems in assembly.
Functionally, it may affect and disturb phenomena such as apoptosis.
b. These drugs may not only disrupt the integrity of mature cadherin-based cell–cell adhesions but also attenuate their stimuli-induced disassembly and reassembly.
Other effects such as lack of cell signalling may cause defects in mechanisms such as apoptosis, which require cell interactions.
c. Information is transmitted in the axon through neural or chemical means.
Depolarisation of specific sections of axon results in trannsmission of information.
Axons may be myelinated, and show saltatory conduction which is faster.
d. Na channels and K channels.
Na channels open when the wave of action potential approaches and cause depolarisation.
K channels cause potassium exchange from the cell, which depolarises it.
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