1. Explain the effect of the mutation on the protein that is translated (compare
ID: 257234 • Letter: 1
Question
1. Explain the effect of the mutation on the protein that is translated (compared to the normal protein), if the protein is essential for life.
2. Make one of the three predictions for each scenario below: Harm the organism, May harm the organism, or will have no effect on the organism?
c. Nonsense mutation in the middle of a gene. Explain effect: Prediction Explanation of prediction: d. Silent mutation in beginning of a gene Explain effect: Prediction Explanation of prediction: e. A mutation in the promoter of the gene. Prediction Explanation of prediction:Explanation / Answer
Answer .c Expalained effect= Nonsense mutation in middle of a gene, its effect on protien is that the protein is truncated as nonsense mutation means that genetic code changes to stop codon.
prediction = It will harm the organism because essential protein is not synthesised fully.
Explainationj of prediction= organism is harmed because the protein is not fully synthesised that result in no functioning of protein and hence organism will be affected.
d] silent mutation in beginning of gene
explained effect = silent mutation means a change in codon that codes for same amino acid or no change in functionality of protein. Protien will be functional
prediction = organism will not be harmed.
explaination of prediction = As there is no change in protein then organism not affected.
e] A mutation in the promoter ofm the gene
Expalined effect = mutation in promoter causes the less expression of protein or it can also result in no protein synthesis.
prediction = organism may or may not be affected
Explaination of prediction = As promoter region are essential for binding of RNA polymerase, so if there is mutation then RNA polymerase may bind to it but the gene expression will be low and it will not cause as much affect, while when RNA polymerase does not bind to these region then there is no protein synthesis and harm the organism.
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