Dude, a chromosomally normal male, is married to Dudette, who is also chromosoma

Question

Dude, a chromosomally normal male, is married to Dudette, who is also chromosomally normal. Their son, Dudester, has Klinefelter syndrome.

Please indicate whether each of the following events could have produced the Dudester.

In each case, assume that ALL other phases of cell division occur normally. For example, if the non-disjunction occurs in meiosis I in Dude, this implies that meiosis II in Dude is normal, and so is meiosis I and II in Dudette.

a.         Non-disjunction in meiosis I in Dudette

b.         Non-disjunction in meiosis II in Dudette

c.         Non-disjunction in meiosis I in Dude

d.         Non-disjunction in meiosis II in Dude

I've heard that its b and c, just c, or just a so im a little confused. Please explain why or why not.

Explanation / Answer

The anser is option a.) non-disjunction in meiosis 1 in Dudette.

Dude is a chromosomally normal male and Dudette is a chromosomally normal female. Their son Dudester is having Klinefelter syndrome. This syndrome is called 47 or XXY condition where the males get an extra X chromosome. So their male characterestics will be a littele suppressed compared to normal males. Since it occurs in sex chromosome so it would be a condition produced through meiosis and 2 chromosomally normal persons can produce this condition. This happens when 2 X chromosomes in mother fails to separate during metaphase of meiosis 1. So in some cases the child receives both the X chromosomes from mother or no chromosmes at all. When the child receives 2 X chromosomes from mother and Y chromosome from father Klinefelter sybdrome is produced. Non-disjunction means the failure of a pair of chromosomes to separate normally during cell division. Meiosis I is similar to mitosis.

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