Dude, a chromosomally normal male, is married to Dudette, who is also chromosoma

Question

Dude, a chromosomally normal male, is married to Dudette, who is also chromosomally normal. Their son, Dudester, has Klinefelter syndrome.

Please indicate whether each of the following events could have produced the Dudester.

In each case, assume that ALL other phases of cell division occur normally. For example, if the non-disjunction occurs in meiosis I in Dude, this implies that meiosis II in Dude is normal, and so is meiosis I and II in Dudette.

a.         Non-disjunction in meiosis I in Dudette

b.         Non-disjunction in meiosis II in Dudette

c.         Non-disjunction in meiosis I in Dude

d.         Non-disjunction in meiosis II in Dude

Explanation / Answer

Klinefelter’s syndrome is the genetic condition in which the individual has XXY chromosomal condition. These people having abnormal chromosomes number are always male. Here, the male (Dudester) inherits two X chromosomes due to the nondisjunction of the X chromosome during meiosis I of Dude.  

Nondisjunction causes chromosomal disorders, because the result is often gametes with an abnormal number of chromosomes. Such male may be sterile and show breast enlargement.

Thus, the correct option is (c) Non-disjunction in meiosis I in Dude.

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