A mutation causing an addition or a deletion of one base pair resulted in the pr

Question

A mutation causing an addition or a deletion of one base pair resulted in the production of a nonfunctional mutant protein. The sequences of the normal and mutant proteins are given below. Normal: Met - Leu - Ala - Thr - Gin Mutant: Met - Leu - Ala - His - Pro - lie - Glu - Ser - Thr -... Was this mutation cause by an insertion or a deletion? Below, fill in the codons in the coding sequence of the mRNA that is translated into the mutant protein. If more than one codon is possible, just enter a single codon.

Explanation / Answer

1. Ans. This mutation is by insertion of new codons/amino acids.

Normal mRNA - Met-Leu-Ala-Thr-Gln

2. Ans. Mutant - Met-Leu-Ala-His-Pro-IIe-Glu-Ser-Thr.......

So, in normal strand new amino acid codons are added i.e insertion(shown in bold)

Normal mRNA - Met-Leu-Ala-Thr-Gln

AUG-UUG-GCU-ACU-GAA

Mutant - Met-Leu-Ala-His-Pro-IIe-Glu-Ser-Thr..

AUG-UUG-GCU-CAU-CCU-AUU-GAA-UCC-ACU

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