8. (3pts) ATP hydrolysis is necessary for actin treadmilling. AGREE or DISAGREE

Question

8. (3pts) ATP hydrolysis is necessary for actin treadmilling. AGREE or DISAGREE Reasoning 5A. (2pts) What happens during the stages of dynamic instability in microtubules, and what triggers the change between one stage to the next? B. (2pts) Suppose a microtubule severing protein breaks microtubules in half, forming two microtubules of shorter length. Do you predict that the newly exposed microtubule plus ends will grow or shrink? Please explain your answer. C. (2pts) Suppose you grow microtubules with mutant tubulin subunits that are unable to hydrolyze GTP. Do you expect to see dynamic instability in these microtubules? Please explain your answer

Explanation / Answer

B. Ans- Agree

Filamentous actin (F-actin) form actin network in which monomers of G-actin bound to either ATP and ADP. During elongation of the actin filament, G- actin binds to ATP. Profilin is important for actin polymerization that it binds ATP-actin and inhibits nucleation. The actin filament becomes shrink when the dissociation rate of ADP-actin is greater than the rate of ATP-actin. When the rate of association of ATP-actin and the rate of loss of ADP-actin are equal then actin treadmilling occurs.

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