2) Describe at least three principle events that occur in the ER with regard to

Question

2) Describe at least three principle events that occur in the ER with regard to protein production and/or modifications? If there was a mutation in the enzyme/step what would result. You can choose just one of the three to explain the resulting defect in this process.

3) What are the criteria that define a bona fide sorting signal? Provide a specific example of a sorting signal and cellular location to illustrate your answer.

4) Is it a reasonable to say that exocytosis and endocytosis are “different sides of the same coin?” Either support or refute this statement by describing the processes (exo- and endo-) and discuss 3-4 of the key molecules involved in either or both processes.

Explanation / Answer

2.) ER is of two types - RER and SER.

Any mutation in the step will produce the protein without SRP and all protein will remain in cytosol.

3.) Protein sorting signal are the sequence of amino acid which directs the localisation of a protein inside the various cellular compartments. Some criteria defining the signals are-

4.) Both exocytosis amd endocytosis are the opposite processes and exocytosis is the process of export the material through vesicle binding at membrane and endocytosis is the process of import of material by engulfing.

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