2) Compare the following peptides (A-D) to answer the following questions. More

Question

2) Compare the following peptides (A-D) to answer the following questions. More than 1 of the peptides may answer the question. The same peptide may fit more than 1 question. (from Bates at UCLA) A. val-ala-phe-ile B. leu-lys-arg-his C. cys-asn-glu-tyr D. gly-met-trp-ser Q1. Which has the most charged groups at pH 7? Q2. Which is the most hydrophobic? Q3. Which would carry a net negative charge at pH 10? Q4. Which would carry a net negative charge at pH 4? Q5. Which would be most likely to be at the interior of a protein's native globular conformation in aqueous (water) environment?

Explanation / Answer

Peptides

Q1. peptide with most charged groups at pH 7

B. leu-lys-arg-his

Q2 Most hydrophobic peptide

A. val-ala-phe-ile

Q3 peptide carrying net negative charge at pH 10

C. cys-asn-glu-tyr

Q4 peptide carrying net negative charge at pH 4

C. cys-asn-glu-tyr

Q5. which would most likely to be at the interior of a proteins native globular conformation in aqueous environment

A. val-ala-phe-ile

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