A sample problem - A highly virulent strain of a common and prev innocuous virus

Question

A sample problem - A highly virulent strain of a common and prev innocuous virus has been discovered and you have decided to conduct a series of experiments to understand what has caused this new strain of virus to be so virulent. Fortunately, the innocuous strain was known to have a small, linear double-stranded DNA genome with nly a few genes. We find that the virulent strain has two new genes. Innocuous strain: Virulent strain: geneA geneB geneC geneA geneB geneC geneD geneE -l Design an experiment to test if geneD is sufficient for the virulence of this type of virus.

Explanation / Answer

The gene D can be isolated and introduced into a nonvirulent gene. This can help to identify whether the gene D alone is responsible for virulence. To know this, transformed nonvirulent virus with gene D is infected into a mouse or any other laboratory animal. If the transformed nonvirulent virus able to cause disease in the animal, then it can be known that gene D alone is responsible for virulence and introduction of gene D into nonvirulent virus transformed it into virulent strain. if gene D alone does not cause infection in mouse with transformed virus, may be gene D requires another gene (gene E) to cause infection. Another mouse is infected with tranformed nonvirulent virus containing both geneD and E. If this strain causes infection it can be concluded that gene D alone is not sufficinet to cause infection and gene E is also required.

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.