BIOCHEMISTRY, AND MOLECULAR BIOLOGY Multiple Genetic Differences between the Mon

Question

BIOCHEMISTRY, AND MOLECULAR BIOLOGY Multiple Genetic Differences between the Monkeypox and Variola Viruses V. utorov, I. Ryazankina, R. Sisler, J. s. N. Shchelkunov, A. V. Totmenin, P. F.Safronov, V N. A. Petrov, I. V. Babkin, E. A. Uvarova, M. V P. B. Jahrling. B. Moss, and Academician L. S. Sandakhchiev Received December 7, 200 The elimination of ariola, an extremely dangerous radic disease resulting from remains sion from animals to humans in he rainforest zone of human epidemic disease, was the first and st western Africa. The transmission of mon- the only example of a successful fight central and to 12 the aegis of World Health Organization disease under between variola and monkeypox by due to the fact the main difference characterized a virus, which belongs to the genus Ortho- ower effectiveness of transmission of the family Poxviridac and causes from human pared to variola virus. practice has demonstrated the effective- nificantly was assumed that program. differ with respect to the genetic designed on the basis of closely related virus be the evolutionary precursor of variola vinus term medical vaccinia vinus, Mass vaccination of people and thor. 120. observations conducted in 1970-1995 revealed ough epidemiological control Thereupon, vaccination variola all occurred in the former Zaire (the Democratic Repub onkeypox in against variola and other infections induced by closely to im related orthopox humans was attracted by the mass Since then, a large group of people that are not pro- number of inferred cases of this infection exceeded 500 tected from orthopoxviruses has been formed. There- 4, 5) By early 1999, an additional several hundred zoonoses induced by orthopoxvi suspected monkeypox in cases of host spectrum, such as monkeypox detected [4 cowpox, and buffalopox viruses, has become possible In connection with the epidemiological situation i n human populations. As a result of the broadened cir the Democratic Republic Congo, the questions arose as culation in human populations, these viruses may to whether monkeypox virus can evolve into the epide- acquire new properties and become epidemiologically miologically dangerous variola-like virus and to which dangerous for humans, Monkeypox virus is the most extent the genetic organizations of these viruses are worrying concern for scientists and doctors, because similar. Earlier, the researchers attempted to answer the infection induced by this virus in humans is similar using comparative analy of mapp sequences of some genes 71 the most monkeypox in human was detected in in 986 led to the reliable answer may be obtained only based on compar- Intensive studies performed in 198 ng the ful conclusion that monkeypox in humans is a rare spo- The purpose of this study was sequencing and anal ysis of the ful monkeypox virus genome. We deter- mined the nucleotide sequence of the mon Center for Virology lector Sale Researc genome and compared the data obtained with the vari and Biotechnolog: Konsovo. ola virus DNA structure. We discovered multiple ovosibirsk oblast, 633159 Russia genetic di fferences between monkeypox and variola ruses, which allowed us to conclude that these viruses, being derived from a common ancestor, under- National Institute of Allero' and Infectioas Diseases, went independent e Bethesda, Maryland United States The study was performed on the monkeypox virus Medical Institute of Infectiows Diseases ofUnited States Army Frederic, Maryland U States strain ZAI-96-1-16 (ZAI) isolated in the Democratic

Explanation / Answer

Short answer question: What is the similarity in infection of monkeypox virus and variola virus in humans? What is the purpose of the gene sequencing studies of monkey pox virus genome in comparison to variola virus genome?

Answer: The main purpose of the gene sequencing of the monekypox virus is to unravel any existence of common ancestral genomic features with that of variaola DNA finally to make a conclusion that these two viruses evolved from a common ancestor or not (?) through independent evolution. These paradigms are useful to determine infection levels of variola virus & monkeypox virus in humans

Related Questions

Navigate

• Browse (All)
• Browse B
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.