A 32-year-old woman was treated for mantle cell lymphoma with a nonmyeloablative

Question

A 32-year-old woman was treated for mantle cell lymphoma with a nonmyeloablative bone marrow transplant. Before the transplant and after a donor was selected, STR analysis was performed on the donor and the recipient to find informative alleles. One hundred days after the transplant, engraftment was evaluated using the selected STR alleles. The results from one marker, D5S818, are shown in the top panel. One year later, the patient was reevaluated. The results from the same marker are shown in the bottom panel. Results from engraftment analysis at 100 days (top) and 1 year (bottom) showing marker D5S818. R. recipient; D, donor Was the woman successfully engrafted with donor cells? Explain your answer.

Explanation / Answer

The woman has not successfully engrafted of the donor cells it is because the size of allele at 135 Mb DNA position is not same as the donor. The donor allele size is still 61188 bp but the recipient has 53400 bp allele size after 1 year of engraftation. The size should be equal to work efficiently or functionally inside the cell.

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