Experiments with T4 bacteriophage supported the validity of the genetic code. Wh

Question

Experiments with T4 bacteriophage supported the validity of the genetic code. Which of the following was NOT a key finding from those experiments?

- verification that an inserted base at one position in a gene and a deleted base nearby but downstream alters the reading frame downstream from the deleted base

- verification that the genetic code is read in triplets - verification of the existence of multiple codons for a single amino acid - verification that translation proceeds in a 5 to 3 direction

Explanation / Answer

Answer a) verification that an inserted base at one position in a gene and a deleted base nearby but downstream alters the reading frame downstream from the deleted base.

Reason - This was a classical experiment performed by 4 scientists Sydney Brenner, Francis Crick, R.J. Watts-Tobin and Leslie Barnett using bacteriophage T4. Key findings of their experiment were that the Genetic code consists of triplet codons. they created frameshift mutations using proflavin mutagen. they demonstrated that these frameshift mutations (due to insertion of single base) could be reversed by deletion of another single base nearby the insertion region but in downstream. in this way, the reading frame downstream of deletion is restored as normal. and only the region consists of insertion and deletion may code for altered amino acids, but the downstream reading frame was restored.

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