A \"normal\" polypeptide has the following mRNA sequence: 5\'-AUG CCU GAG GGA UC

Question

A "normal" polypeptide has the following mRNA sequence: 5'-AUG CCU GAG GGA UCA GUG CAC CCA AAG CUA AUC GCC AUC UGA-3' Rank the effects of the following point mutations in terms of the severity of their effect upon protein structure (and therefore function). Use the codon table provided earlier to help you. AUG CCU GAG GGA UCA GUG CAU CCA AAG CUA AUC GCC AUC UGA AUG CCU GAG GGA UCA GUG CAC CCA AAG CUA AUC GCC AUC UGA AUG CCU GAG GGA UAA GUG CAU CCA AAG CUA AUC GCC AUC UGA AUG CCU GAG GGA UCA GUG CAC CCA UAG CUA AUC GCC AUC UGA

Explanation / Answer

in order from most to least severe: C) this is the most severe because uaa is a stop codon. the protein will be terminated here and almost definitely not functional. D) this is likely to be a serious mutation because it changes the intended amino acid to a stop. because c is further upstream than d it will be more of a problem. A) a will be least severe of the mutations because the amino acid will be the same B) there is no mutation here

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