Describe the specific problem that might arise during DNA replication of bacteri

Question

Describe the specific problem that might arise during DNA replication of bacteria if the protein listed were absent or nonfunctional. I am looking for a description of how DNA replication will be impacted – not simply that the bacteria will die – which it well (listed in alphabetical order):

a.DNA ligase

b.DNA pol III

c.DNA polymerase I

d.DNAa

e.Helicase

f.Primase

g.Sliding clamp

h.Topoisomerase/DNA gyrase

a.DNA ligase

b.DNA pol III

c.DNA polymerase I

d.DNAa

e.Helicase

f.Primase

g.Sliding clamp

h.Topoisomerase/DNA gyrase

Explanation / Answer

1.DNA ligase: in its absence the okazaki fragments, formed on one of the strand DNA, will not get joined and resealed to form a complete strand of new DNA.

2. DNA polymerase III:the proofreading of New DNA strand and its error may not get repaired in absence of DNA polymerase III.

3. Polymerase 1:in irs absence the DNA strand will not be formed through elongation on RNA primers.

4.helicase:its absence will not allow opening of parent DNA strand for replication.

5. Primase: in absence of this enzyme, RNA primers will not be formed to initiate DNA elongation.

6. Sliding clamp: in absence of this protein clamp DNA polymerase will get dissociated from DNA template strand and replication will stop.

7.topoisomerase: it helps in unwinding by removing temsionin supercoiled DNA. In its absence, DNA strand will break while replicating due to coiling tension generated.

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