Fictional data: Mutations in a paternally imprinted gene “unhappy” are known to

Question

Fictional data: Mutations in a paternally imprinted gene “unhappy” are known to underlie the negative emotional state of individuals. Different mutations result in different degrees of the phenotype: a non-synonymous point mutation (h) leads to being constantly unhappy with strangers, while deletion of the gene () results in being unhappy with the whole world ( strangers, friends, family and themselves) that swiftly advances to a full-blown suicidal depression (the normal allele of this gene is denoted as H). Give the expected phenotypic outcome for kids from the following parents:

Parental genotypes

Kids

Mother

Father

% of normal

% of unhappy with others

% of severely unhappy

Hh

Hh

HH

H

HH

h

H

HH

h

H

h

Hh

Parental genotypes

Kids

Mother

Father

% of normal

% of unhappy with others

% of severely unhappy

Hh

Hh

HH

H

HH

h

H

HH

h

H

h

Hh

Explanation / Answer

HhxHh- 3:1 the 3/4 will be happy the 1/4 will be hh meaning they are unhappy with others HHx(-)H- all will be normal (note: you will have one genotypic class that is H(-) but i am assuming that the H is a dominant trait and therefore is happy with others HHx(-)h- this is the same as above assuming H is dominant over all the other genotypes (-)HxHH- all will be normal (-)hx(-)H- 1/4 severe, 1/4 unhappy with others, 1/2 normal (-)hxHh- 1/2 normal 1/2 unhappy Note that ll of these answers were done by a simple punnet square in which you line up one genotype on the x-axis and the other on the y-axis

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