I am to design a short case study for the enzyme, Amylase, but I am having troub

Question

I am to design a short case study for the enzyme, Amylase, but I am having trouble identifying the medical relevance of Amylase. One of my resources said that Amylase is not ordered for specualtion of a pancreatic disorder, due to Lipase being more sensitive for detection of a pancratic disorder. This is my case study so far: "A 44-year-old male came into his doctor’s office with complaints of pain, nausea, and vomiting. The patient also complained of not being able to sleep most nights. The patient had not seen a physician in nearly 5 years. The doctor ordered a CBC and CMP. Upon receiving the results from the laboratory, the doctor noticed no abnormal values on his CMP. The CBC, however, showed a slight increase in the about of white blood cells that were in circulation. The doctor ordered a lipase and amylase on the sample that had been collected for the CMP. The lipase came back as being significantly elevated. The amylase also came back as being 3 times higher than the normal reference range. The patient had hyperamylasemia. Coupled with hyperlipidemia, the doctor could confirm that the patient was suffering from a pancreatic disorder." I am not seeing a way to explain the clinical significance of amylase, when is seems that lipase is the more definitve test for speculation of a pancreatic disorder. Some help on this would be greatly appreciated.

Explanation / Answer

Amylase refers to a category of enzymes that digest the carbohydrates.the basis is digestion of complex carbohydrates like starch into soluble sugars.amylase is found both in saliva and pancreas.

Lipase is the digestive enzymes that breaks down dietary fat molecules like triglyceride substrate into monoglyceride and free fatty acids.

Amylase starts its works from the salivary gland itself.so when testing we have to check for pancreatic amylase specifically.and also serum lipase offers higher sensitivity than serum amylase.

Serum lipase has bigger diagnostic window because it's increased for a longer amount of time.

But to establish a definitive diagnosis of pancreatic disorder both amylase and lipase should be tested.

The most specific test to diagnose pancreatic disorder from other disorder is actually the clearance ratio of amylase vs clearance ratio of creatinine.so actually serum amylase is important.

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