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I am synthesizing 2-aminobenzoyl glycine from ortho-aminobenzoic acid and acetic

ID: 801357 • Letter: I

Question

I am synthesizing 2-aminobenzoyl glycine from ortho-aminobenzoic acid and acetic acid.


I am including the synthesis I prepared - but I'm not sure about protecting the amine group. My main concern is that the amide formed would be reactive to SOCl2.


Also - would H3O+ also hydrolyze the admide in the product back to a carboxylic acid?


I am synthesizing 2-aminobenzoyl glycine from ortho-aminobenzoic acid and acetic acid. I am including the synthesis I prepared - but I'm not sure about protecting the amine group. My main concern is that the amide formed would be reactive to SOCl2. Also - would H3O+ also hydrolyze the admide in the product back to a carboxylic acid?

Explanation / Answer

Yes, it is correct.

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