Amino Acids and Proteins Please answer the following: 1. 2. I\'ve tried Histide,

Question

Amino Acids and Proteins

Please answer the following:

1.

2. I've tried Histide, Lysine and Arginine and it was wrong.

Map o sapling learning Put these steps in the mechanism of chymotrypsin catalysis in order from first to last. Note that your textbook may not break out each of these steps individually, but all steps should be ordered. (There will be eight steps.) irst step last step His 57 donates H to Ser 195 O, leading to collapse of tetrahedral intermediate. the portion (N-terminal end) of original substrate with the new carboxylate terminus diffuses away His 57 catalyzes removal of H from Ser 195 hydroxyl. additional steps listed below His 57 donates H to N of sissile peptide bond tetrahedral intermediate decomposes.

Explanation / Answer

ORDER :

His 57 catalyzes removal of H from Ser 195 hydroxyl.

. Ser 195's nucleophilic O attacks carbonyl C of substrate.

His 57 donates H to N of sissile peptide bond, tetrahedral intermediate decomposes.

C- terminal portion of oribinal substrate with its new amino acid terminus diffuses away.

water donates H to His 57. Resulting OH attacks carbonyl of remaining substrate.

His 57 donates H to Ser 195 O, leading to collapse of tetrahedral intermediate.

N-terminal portion of original substrate with its new carboxy terminus diffuses away

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