Enzymatic mechanisms often involve protonation and deprotonation steps (sometime

Question

Enzymatic mechanisms often involve protonation and deprotonation steps (sometimes simultaneously). Amino acid side chain functional groups are oriented in the enzyme active site to donate or remove protons. Consider the following mechanistic step in the action of citrate synthase. Which functional group is acting to deprotonate Acetyl CoA? carboxylate carbonyl amide imidazole ring That functional group can be found in the side chain of what amino acids? aspartic acid arginine histidine glutamic acid These amino acids are classified as acidic or basic? basic acidic

Explanation / Answer

For the above shown transformation,

The functional group acting to deprotonated Acetyl CoA,

carboxylate

The functional group found on side chain of amino acid,

asparatic acid

glutamic acid

The amino acids referred to as above are classified as,

acidic

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