Enzymatic mechanisms often involve protonation and deprotonation steps (sometime

Question

Enzymatic mechanisms often involve protonation and deprotonation steps (sometimes simultaneously). Amino acid side chain functional groups are oriented in the enzyme active site to donate or remove protons. Consider the following mechanistic step in the action of citrate synthase. Which functional group is acting to protonate Acetyl CoA? imidazole ring amide carbonyl carboxylate That functional group can be found in the side chain of what amino acids? proline glutamic acid tryptophan histidine These amino acids are classified as acidic or basic? basic acidic

Explanation / Answer

1) a) imidazole ring ( Acetyl coA enzyme abstact proton from N-H of imidazole ring is shown in figure)

2) b) glutamic acid ( amino acid has acid functionl group as a side chain, in given options, glutamicacid is only has the acid group as a side chain)

3) b) acidic ( amino acid has acid group so the amino acid has been classified as a acidic )

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