A 39-year-old kindergarten teacher has contracted the influenza virus from one o

Question

A 39-year-old kindergarten teacher has contracted the influenza virus from one of his students. A germinal center from the teacher is shown 7-days post-infection (right). The large, white circle represents the germinal center, and the smaller, colored circles represent B cells with different affinities to influenza. Which of the choices shown below would best represent the B cell population found in the same germinal center approximately two and three weeks later, respectively? A. Germinal center A: germinal center B B. Germinal center A: germinal center E C. Germinal center B: germinal center C D. Germinal center B: germinal center D E. Germinal center E: germinal center C

Explanation / Answer

Answer is option D. Germinal center B; germinal center D.

The initial immune response is of IgM against the vital infection. Once the virus is identified and presented, the B cells undergo clonal proliferation and start differentiating through somatic hypermutation. This mutation in the DNA of the vb cells occurs until a relevant B cell clone which is able to produce specific antibody against the virus is produced.

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