A 37-year-old man is diagnosed with Philadelphia chromosome-positive (Ph+) chron

ID: 263611 • Letter: A

Question

A 37-year-old man is diagnosed with Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML).

a. What is the molecular mechanism that makes this kind of cancer?(1/2 page)

b. What is the first-line treatment for CML and what is the rationale for this pharmacotherapy?(1/4 page)

c. What are the mechanisms of resistance to imatinib pharmacotherapy of CML?(1/4 page)

d. What other cancers and diseases are effectively treated with imatinib?(1/4 page)

e. What are the common and important side effects of therapy with imatinib(1/4 page)

A 37-year-old man is diagnosed with Philadelphia chromosome-positive (Ph+) chron

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