What charge do histones that are bound to DNA possess and why? Question 9 option

Question

What charge do histones that are bound to DNA possess and why?

Question 9 options:

negative to be able to hydrogen bond to the base pairs

positive to be able to hydrogen bond to the base pairs

positive to bind the negatively charged phosphates of the DNA backbone

negative to bind to the positively charged hydroxyl group of the DNA backbone

negative to be able to hydrogen bond to the base pairs

positive to be able to hydrogen bond to the base pairs

positive to bind the negatively charged phosphates of the DNA backbone

negative to bind to the positively charged hydroxyl group of the DNA backbone

Explanation / Answer

Histones are proteins which have a arginine (R) and lysine (K) residues on their surface. These amino acids are positively charged at physiological pH and hence can form ionic interactions with negatively charged phosphate groups in DNA.

- positive to bind the negatively charged phosphates of the DNA backbone

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