1. A man with Type 2 diabetes is receiving a combination of oral drugs to mainta
ID: 89215 • Letter: 1
Question
1. A man with Type 2 diabetes is receiving a combination of oral drugs to maintain glycemic control. He becomes hypoglycemic one afternoon and ingests some orange juice and two chocolate bars-all containing abundant amounts of sugars. Nonetheless his blood glucose levels remain low, his symptoms persist. Which of the following antidiabetic drugs that he was taking accounted for the failure of oral sugars to restore his plasma glucose? WHY? A. Acarbose B. Metformin C. Thiazolidinediones D. Sulfonylurea 1. A man with Type 2 diabetes is receiving a combination of oral drugs to maintain glycemic control. He becomes hypoglycemic one afternoon and ingests some orange juice and two chocolate bars-all containing abundant amounts of sugars. Nonetheless his blood glucose levels remain low, his symptoms persist. Which of the following antidiabetic drugs that he was taking accounted for the failure of oral sugars to restore his plasma glucose? WHY? A. Acarbose B. Metformin C. Thiazolidinediones D. Sulfonylurea 1. A man with Type 2 diabetes is receiving a combination of oral drugs to maintain glycemic control. He becomes hypoglycemic one afternoon and ingests some orange juice and two chocolate bars-all containing abundant amounts of sugars. Nonetheless his blood glucose levels remain low, his symptoms persist. Which of the following antidiabetic drugs that he was taking accounted for the failure of oral sugars to restore his plasma glucose? WHY? A. Acarbose B. Metformin C. Thiazolidinediones D. SulfonylureaExplanation / Answer
1) Type 2 diabetes is treated with different classes of oral hypoglycemic drugs. Sulfonylurea exhibits its hypoglycemic effect by acting on the ATP sensitive potassium channels in the islet of Langerhans and release of insulin. Metformin decreases hepatic production of glucose and increases insulin sensitivity of the peripheral tissues. Thiazolidinediones acts on peroxisome proliferator activated receptor - gamma (PPAR) in adipocytes to promote adipogenesis and fatty acid uptake. Acarbose is an alpha-glucosidase inhibitor. Acarbose decreases blood glucose level by slowing the digestion of carbohydrates. Therefore, the patient in the question is taking acarbose so that he remains hypoglycemic even after taking chocolate bars containing abundant amount of sugars. The answer is option (A) Acarbose.
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