73. Several prostaglandin derivatives were synthesized in the lab and tested for

Question

73. Several prostaglandin derivatives were synthesized in the lab and tested for their ability to sensitize a prostaglandin-specific G-protein coupled receptor and modulate cholesterol metabolism. According to the information below, which of the prostaglandin derivatives (PD) would form the most stable complex with the receptor?

A. PD1, KD = 1 nM

B. PD2, KD = 1 µM

C. PD1, KM = 1 nM
D. PD2, KM = 1 µM

74. In the cAMP-dependent activation of pyruvate kinase, which of the following amino acids is phosphorylated?

A. His
B. Thr

C. Tyr

D. Ser
E. Lys

Explanation / Answer

73) PD1,KD=2nM is the prostaglandin derivateive which would form most stable complexe with receptors.So i think option 1 is correct.

74) Ser is the amino acid which is phosphorylated in the cAMP-dependent activation of pyruvate kinase.So i think option D is correct.

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