Does Depletion of Three BMP Antagonists from Spemann\'s Organizer Lead to a Cata

Question

Does Depletion of Three BMP Antagonists from Spemann's Organizer Lead to a Catastrophic Loss of Dorsal Structures? Any future experiments that you think could be done to continue to prove your response. Explain and give your personal take. Does Depletion of Three BMP Antagonists from Spemann's Organizer Lead to a Catastrophic Loss of Dorsal Structures? Any future experiments that you think could be done to continue to prove your response. Explain and give your personal take. Does Depletion of Three BMP Antagonists from Spemann's Organizer Lead to a Catastrophic Loss of Dorsal Structures? Any future experiments that you think could be done to continue to prove your response. Explain and give your personal take.

Explanation / Answer

Spemann-Mangold’s organiser the dorsal blastoporal tip plays the main role to develop the ventral-dorsal axis by activating signalling cascade for neural tube, notochord etc during the early gastrulation period. In the legendary experiment of Spemann-Mangold they have demonstrate that the role of blastoporal tip. This tip secrets BMP (bone morphogenic protein) antagonist like noggin, chordin, follistatin etc which protect the ectoderm and mesoderm from epidermal and ventralisation signals repectively. However not only these protein also -catenin etc also is negatively regulate the Mrna level of BMP. Thus inhibition of any one of these antagonist is not enough to affect the BMP antagonism. Three antagonist follistatin, chordin, and noggin have a overlapping role in the antagonism effect and thus even double mutant between any of these two are also not able to able to show the effect. But a triple negative condition there is a catastrophic failure of organiser function. The gastrulation period is highly important for the observing the effect of these inhibition. In absence of BMP inhibition there is least problem with the early signalling process for ventral side development but in later if the BMP singnal is remains in uninhibited condition then develop excessive amounts of ventral tissue at the expense of dorsal structures. Thus, these antagonists are highly required to work in a combined manner to provide the organiser effect.

Knock down or mutant expressing gene of these BMP antagonists shows the role of these proteins in organiser. But the inhibition has o tested in different condition with single, double and triple mutant to find out their exact role

Related Questions

Navigate

• Browse (All)
• Browse D
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.